Model Policy for the Use of Controlled Substances for the Treatment of Pain,

Breakthroughs and Challanges in the Pharmacological Management of Common Pain Conditions.  The US Department of Health and Human Services.The Office on Women's Health. 

Frequently Requested Documents
Opioid Chemistry
Opioid Intolerance Decision Algorithm
Opioid Pharmacokinetics
Opioid Metabolic Pathways
Opioid Metabolite Predictability Chart and References

Dosing and Pharmacokinetic Data and Guidelines
There is a useful electronic Narcotic Analgesic Conversion Calculator available at Globalrph.com, or click here for the direct link. Please note, this service is owned and copyrighted by Globalrph.com.  Paindr.com therefore assumes no liability whatsoever for anybody that uses this tool to predict or otherwise calculate narcotic (opioid doses) .  The globalrph policy states, "Service is intended to be used for informational purposes only and is not intended to be used for medical diagnosis or treatment or to substitute for a medical diagnosis and/or treatment rendered or prescribed by a physician or competent healthcare professional. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon."

The tables below are provided courtesy of Ruth J. Perkins, B.S., M.A., Pharm.D. BCPS.  Dr. Perkins holds a B.S. in Biology from Harpur College of SUNY/Binghamton, an M.A. in Pharmacology from Boston University, a B.S. / Pharm.D. from Albany College of Pharmacy and is a Board Certified Pharmacotherapy Specialist.  Follow this link to Dr. Ruth Perkins' curriculum vitae.  

Complex Opioid Metabolite Data:  These two tables list various parameters, including how specific opioid metabolites are handled by the body, and how their metabolism varies with certain disease states and end-organ dysfunction.

Dosing Guidelines:  These two tables include equi-analgesic comparisons and dosing guidelines in narcotic naïve adults and children.

Click here to view Systematic Review of Intrathecal Pump Therapy